Leonardo, although there is not a single correct way to make a responsive Designer, what we can do is share our personal practice.
In my case, I don’t usually set a size for the inputs, but for the div that contains the input, label, etc.
The second point is to set a minimum size for the form/div that contains all inputs, in my case I set a minimum size of 320px, but this is up to you. Another interpresante point, a set a maximum size for the form/div.
I particularly prefer to work with the concept of Mobile-First, first I define my rules for small screens, then I adapt the layout for large screens.
.linha {
    clear: both;
    min-width: 320px;
    max-width: 65em;
    position: relative;
    right: 0px;
    left: 0px;
    margin: auto;
}
.coluna {
    float: left;
}
.coluna label,
.coluna input {
    width: 100%;
}
.coluna label:after {
    content: ':'
}
@media only screen {
    .pequeno-12 {
        width: 100%;
    }
}
@media only screen and (min-width: 40em) {
    .coluna label {
        float: right;
        text-align: right;
        margin-top: 2px;
        margin-right: 5px;
    }
    
    .mediano-4 {
        width: 33.33333%;
    }
    .mediano-8 {
        width: 66.66667%;
    } 
}
@media only screen and (min-width: 65em) {
    .grande-2 {
        width: 16.66667%;
    }
    .grande-4 {
        width: 33.33333%;
    } 
}
<form>
    <div class="linha">
        <div class="coluna pequeno-12 mediano-4 grande-2">
            <label for="cmpA">Nome da Empresa</label>
        </div>
        <div class="coluna pequeno-12 mediano-8 grande-4">
            <input id="cmpA" type="text" name="empnome" maxlength=80/>
        </div>
        <div class="coluna pequeno-12 mediano-4 grande-2">        
            <label for="cmpB">Criada Em</label>
        </div>
        <div class="coluna pequeno-12 mediano-8 grande-4">
            <input id="cmpB" type="date" name="data" maxlength=10/>
        </div>
    </div>
    <div class="linha">
        <div class="coluna pequeno-12 mediano-4 grande-2">
            <label for="cmpC">Responsavel</label>
        </div>
        <div class="coluna pequeno-12 mediano-8 grande-4">
            <input id="cmpC" type="text" name="empnome" maxlength=80/>
        </div>
        <div class="coluna pequeno-12 mediano-4 grande-2">        
            <label for="cmpD">Ultima Vistoria</label>
        </div>
        <div class="coluna pequeno-12 mediano-8 grande-4">
            <input id="cmpD" type="date" name="data" maxlength=10/>
        </div>
    </div>
</form>
 
 
							
							
						 
From what I understand, just define the property
min-widthin hisinput.– Renan Gomes