To write a comment in Python, just put a # before the text that will be the comment:
# Isto é um comentário
The Python interpreter will ignore everything after the # until the end of the line.
You can also insert them in a line that has code, after the code separated by two spaces (as recommended by PEP8):
print ('Olá, mundo!')  # Este texto não será considerado
When you run the above code, you will see only the output 'Olá, mundo!', the remainder will be ignored by the interpreter.
To comment multiple lines, you can do so:
"""
Este é um
comentário
de várias
linhas
"""
Multi-line comments are often used to write "docstrings", as can also be seen in the PEP8.