1
private void GerarPDF(string pCaminhoArquivoPDF)
{
    Document doc = new Document();
    // Aqui acontece o erro
    PdfWriter.GetInstance(doc, new FileStream(pCaminhoArquivoPDF,FileMode.Create));
    try
    {
        Paragraph p = new Paragraph(textBox1.Text);
        doc.Open();
        doc.Add(p);
        doc.Close();
    }
    catch (Exception ex)
    {
        MessageBox.Show(ex.StackTrace);
        //throw;
    }
}
private void OndeGerar(Object o,EventArgs e)
{
    GerarPDF( @"C:\Users\CAIO\Desktop\PDF's");
}
						
Try running Visual Studio in administrator mode.
– Pedro Paulo
Normally denied access error may be that the path you are trying to access doesn’t even exist. This has happened to me before and I kept thinking that it could be something of access, but in the end, it was I who was passing the wrong way!
– perozzo
Can that quote there, from
PDF's?– Marcelo Shiniti Uchimura
@Marcelouchimura Yes, "Arnaldo" :)
– Leandro Angelo